Rescue teams said it was an 'absolute miracle' more people were not killed when the lorry, laden with household goods, left the busy A56 and tumbled on to the west-bound carriageway of the M56, at junction 11 near Preston Brook, in Runcorn near Warrington.
Cheshire Police said two passing motorists were treated for shock after witnessing the accident just before 3.30pm.
The tragedy comes just days after the M5 disaster where seven people died and 51 were injured on Friday night.
A spokeswoman for the North West Air Ambulance said: 'One male fatality has been confirmed - the lorry driver sadly died at the scene. Read More