Mexico's human rights commission, CNDH, said 5,397 people had been reported missing since President Felipe Calderon declared war on the drug cartels.
A United Nations study has suggested the security forces may have played a part in the disappearance of some of those missing.
Mr Calderon has deployed 50,000 troops as part of his war on the cartels.
The CNDH collated data provided by relatives and by state authorities and included all of those "reported missing or absent".
The commission said 3,457 of those disappeared were men and 1,885 women, while there was no data on the remaining 55 cases. (read more)